• Product NameC646
• Brief DescriptionInhibitors
• Purification95.00%
• Biological ActivityC646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM in a cell-free assay. Preferentially selective for p300 versus other acetyltransferases.
• Target NameEpigenetic Reader Domain inhibitor
• CAS No. 328968-36-1
• Calculated MW 445.42
• Formulation C24H19N3O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C(C=C(C(=C1)C2=CC=C(O2)/C=C\3/C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C)[N+](=O)[O-])C
  Pathways:Chromatin/Epigenetic
  Receptor:p300/CBP
  Boling pt:
  Melting pt:
  Solubility:DMSO: 13 mg/mL (29.18 mM)
  Appearance:Red Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bowers EM, et al. Chem Biol, 2010, 17(5), 471-482.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting