• Product NamePFK-015
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityPFK-015 is an effective inhibitor of PFKFB3 with IC50 of 110 nM (recombinant PFKFB3) and inhibits PFKFB3 activity in Y cells with IC50 of 20 nM.
• Target NameGlucokinase inhibitor
• CAS No. 4382-63-2
• Calculated MW 260.29
• Formulation C17H12N2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C1=CC=C2C(=C1)C=CC(=N2)/C=C/C(=O)C3=CC=NC=C3
  Pathways:Metabolism
  Receptor:PFKFB3
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL warmed (7.68 mM); DMSO: 19 mg/mL warmed (72.99 mM)
  Appearance:Green Crystal Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Clem BF, et al. Mol Y Ther. 2013, 12(8), 1461-1470.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting