• Product NameBRL54443
• Brief DescriptionInhibitors
• Purification99.60%
• Biological ActivityBRL 54443 is a 5-HT1E and 5-HT1F receptor agonist with pKi of 8.7 and 9.25, respectively, with a weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors.
• Target Name5-HT Receptor agonist
• CAS No. 57477-39-1
• Calculated MW 230.31
• Formulation C14H18N2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:CN1CCC(CC1)C1=CNC2=C1C=C(O)C=C2
  Pathways:GPCR/G Protein; Neuroscience
  Receptor:5-HT1A; 5-HT1B; 5-HT1D; 5-HT1E; 5-HT1F
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL (8.68 mM); DMSO: 46 mg/mL (199.73 mM)
  Appearance:Gray Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Janssen P, et al. Eur J Pharmacol. 2004, 492(2-3), 259-267.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting