• Product NameZM 39923 hydrochloride
• Brief DescriptionInhibitors
• Purification97.57%
• Biological ActivityZM 39923 hydrochloride is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.
• Target NameEGFR inhibitor; JAK inhibitor; Others inhibitor
• CAS No. 58753-54-1
• Calculated MW 367.91
• Formulation C23H25NOHCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:Cl.CC(C)N(CCC(=O)C1=CC2=CC=CC=C2C=C1)CC1=CC=CC=C1
  Pathways:Angiogenesis; Others; Chromatin/Epigenetic; JAK/STAT signaling; Tyrosine Kinase/Adaptors; Stem Cells
  Receptor:EGFR; JAK1; JAK3; TGM2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 80 mM
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Brown GR, et al. Bioorg Med Chem Lett. 2000, 10(6), 575-579.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting