• Product NameSB-505124
• Brief DescriptionInhibitors
• Purification99.92%
• Biological ActivitySB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM in cell-free assays, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.
• Target NameALK inhibitor
• CAS No. 694433-59-5
• Calculated MW 335.4
• Formulation C20H21N3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:O.Cl.CC1=CC=CC(=N1)C1=C(N=C(N1)C(C)(C)C)C1=CC2=C(OCO2)C=C1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK4; ALK5
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 67 mg/mL (199.76 mM); DMSO: 67 mg/mL (199.76 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. DaCosta Byfield S, et al. Mol Pharmacol. 2004, 65(3), 744-752.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting