• Product NameML141
• Brief DescriptionInhibitors
• Purification99.36%
• Biological ActivityML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM.
• Target NameCDK inhibitor
• CAS No. 71203-35-5
• Calculated MW 407.49
• Formulation C22H21N3O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC=C(C=C1)C1CC(=NN1C1=CC=C(C=C1)S(N)(=O)=O)C1=CC=CC=C1
  Pathways:Cell Cycle/Checkpoint
  Receptor:cdc42
  Boling pt:
  Melting pt:
  Solubility:DMSO: 81 mg/mL warmed (198.77 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chen HY, et al. EMBO Mol Med. 2013, 5(5), 723-736.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting