• Product NameNSC319726
• Brief DescriptionInhibitors
• Purification98.97%
• Biological ActivityNSC319726 is a mutant p53R175 reactivator; inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM); shows no inhibition for p53 wild-type cells.
• Target Namep53 inhibitor
• CAS No. 71555-25-4
• Calculated MW 234.32
• Formulation C11H14N4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C/C(=N\NC(=S)N1CCC1)/C2=CC=CC=N2
  Pathways:Apoptosis
  Receptor:p53 (R175)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 19 mg/mL (81.08 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Yu X, et al. Y Cell. 2012 May 15;21(5):614-25.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting