• Product NamePF-562271
• Brief DescriptionInhibitors
• Purification97.56%
• Biological ActivityPF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
• Target NameCDK inhibitor; FAK inhibitor; PYK2 inhibitor
• CAS No. 717907-75-0
• Calculated MW 507.49
• Formulation C21H20F3N7O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN(S(C)(=O)=O)C1=C(CNC2=C(C(F)(F)F)C=NC(NC3=CC=C(NC(C4)=O)C4=C3)=N2)C=CC=N1.OS(C5=CC=CC=C5)(=O)=O
  Pathways:Angiogenesis; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling
  Receptor:CDK1/CyclinB; CDK2/CyclinE; CDK3/CyclinE; FAK; PYK2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL warmed (197.04 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Roberts WG, et al. Y Res, 2008, 68(6), 1935-1944.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting