• Product NameOsu-03012
• Brief DescriptionInhibitors
• Purification98.52%
• Biological ActivityOSU-03012 (AR-12) is a potent inhibitor of recombinant PDK-1 with IC50 of 5 μM in a cell-free assay and 2-fold increase in potency over OSU-02067.
• Target NamePDK inhibitor
• CAS No. 742112-33-0
• Calculated MW 460.45
• Formulation C26H19F3N4O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:NCC(=O)NC1=CC=C(C=C1)N1N=C(C=C1C1=CC2=C(C=C1)C1=CC=CC=C1C=C2)C(F)(F)F
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PDK1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 11 mg/mL (23.88 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhu J, et al. Y Res, 2004, 64(12), 4309-4318.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting