• Product NameMK8745
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityMK-8745 is a potent and selective Aurora A inhibitor with IC50 of 0.6 nM, more than 450-fold selectivity for Aurora A over Aurora B.
• Target NameAurora Kinase inhibitor
• CAS No. 885325-71-3
• Calculated MW 431.91
• Formulation C20H19ClFN5OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:FC1=C(C=CC=C1Cl)C(=O)N1CCN(CC2=NC(NC3=NC=CS3)=CC=C2)CC1
  Pathways:Cell Cycle/Checkpoint; Chromatin/Epigenetic
  Receptor:Aurora A; Aurora B
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 1 mg/mL (2.31 mM); DMSO: 86 mg/mL (199.11 mM)
  Appearance:Brownness Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chowdhury A, et al. Leuk Lymphoma. 2012, 53(3), 462-471.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting