• Product NameCGI1746
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCGI1746 is a potent and highly selective small-molecule inhibitor of the Btk with IC50 of 1.9 nM.
• Target NameBTK inhibitor
• CAS No. 910232-84-7
• Calculated MW 579.69
• Formulation C34H37N5O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1C=C(N=C(NC2=CC=C(C=C2)C(=O)N2CCOCC2)C1=O)C1=C(C)C(NC(=O)C2=CC=C(C=C2)C(C)(C)C)=CC=C1
  Pathways:Angiogenesis
  Receptor:BTK
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 100 mg/mL (172.5 mM); DMSO: 100 mg/mL (172.5 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Di Paolo JA, et al. Nat Chem Biol, 2011, 7(1):41-50.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting