• Product NamePLX4720
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityPLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.
• Target NameBTK inhibitor; Raf inhibitor; Tyrosine Kinases inhibitor
• CAS No. 918505-84-7
• Calculated MW 413.83
• Formulation C17H14ClF2N3O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CCCS(=O)(=O)NC1=C(F)C(C(=O)C2=CNC3=NC=C(Cl)C=C23)=C(F)C=C1
  Pathways:Angiogenesis; MAPK; Proteases/Proteasome
  Receptor:BRK; B-Raf; B-Raf (V600E); C-Raf-1 (Y340D/Y341D); FRK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 83 mg/mL (200.56 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tsai J, et al. Proc Natl Acad Sci U S A, 2008, 105(8), 3041-3046.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting