• Product NameKU0063794
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityKU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2 with IC50 of ~10 nM in cell-free assays; no effect on PI3Ks.
• Target NamemTOR inhibitor
• CAS No. 938440-64-3
• Calculated MW 465.54
• Formulation C25H31N5O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C[C@@H]1CN(C[C@@H](O1)C)C2=NC3=C(C=CC(=N3)C4=CC(=C(C=C4)OC)CO)C(=N2)N5CCOCC5
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:mTORC1; mTORC2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 16 mg/mL (34.36 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Garca-Martnez JM, et al. Biochem J, 2009, 421(1), 29

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting