• Product NameTyrphostin 9
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityTyrphostin 9 is firstly designed as an EGFR inhibitor with IC50 of 460 μM, but is also found to be more potent to PDGFR with IC50 of 0.5 μM.
• Target NameEGFR inhibitor; PDGFR inhibitor
• CAS No. 10537-47-0
• Calculated MW 282.38
• Formulation C18H22N2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)(C)C1=CC(C=C(C#N)C#N)=CC(=C1O)C(C)(C)C
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR; PDGFR
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 56 mg/mL (198.31 mM); DMSO: 56 mg/mL (198.31 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gazit A, et al. J Med Chem, 1989, 32(10), 2344-2352.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting