• Product NameRVX-208
• Brief DescriptionInhibitors
• Purification99.88%
• Biological ActivityRVX-208 is a potent BET bromodomain inhibitor with IC50 of 0.510 μM for BD2 in a cell-free assay, about 170-fold selectivity over BD1. Phase 2.
• Target NameEpigenetic Reader Domain inhibitor
• CAS No. 1044870-39-4
• Calculated MW 370.4
• Formulation C20H22N2O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC(OC)=C2C(=O)N=C(NC2=C1)C1=CC(C)=C(OCCO)C(C)=C1
  Pathways:Chromatin/Epigenetic
  Receptor:BD2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 74 mg/mL (199.78 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Picaud S, et al. Proc Natl Acad Sci U S A. 2013, 110(49), 19754-19759.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting