• Product NameAT13148
• Brief DescriptionInhibitors
• Purification97.00%
• Biological ActivityAT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.
• Target NameAkt inhibitor; PKA inhibitor; ROCK inhibitor; S6 Kinase inhibitor; SGK inhibitor
• CAS No. 1056901-62-2
• Calculated MW 313.78
• Formulation C17H16ClN3O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1=CC(=CC=C1C2=CNN=C2)[C@@](CN)(C3=CC=C(C=C3)Cl)O
  Pathways:Cytoskeletal Signaling; Cell Cycle/Checkpoint; GPCR/G Protein; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
  Receptor:Akt1; Akt2; Akt3; PKA; ROCK1; ROCK2; p70 S6K; RSK1; SGK3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 62 mg/mL (197.59 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Yap TA, et al. Clin Y Res. 2012, 18(14), 3912-3923.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting