• Product NameAZD2461
• Brief DescriptionInhibitors
• Purification98.12%
• Biological ActivityAZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.
• Target NamePARP inhibitor
• CAS No. 1174043-16-3
• Calculated MW 395.43
• Formulation C22H22FN3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1CCN(CC1)C(=O)C1=C(F)C=CC(CC2=NNC(=O)C3=CC=CC=C23)=C1
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair
  Receptor:PARP
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 31 mg/mL (78.39 mM); DMSO: 79 mg/mL (199.78 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Jaspers JE, et al. Y Discov, 2013, 3(1), 68-81.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting