• Product NameIOWH-032
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityIOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 2.
• Target NameCFTR inhibitor
• CAS No. 1191252-49-9
• Calculated MW 545.18
• Formulation C22H15Br2N3O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:BrC1=CC(C=C(Br)C1=O)=C1NOC(=N1)C(=O)NCC1=CC=C(OC2=CC=CC=C2)C=C1
  Pathways:Membrane transporter/Ion channel
  Receptor:CFTR
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL (183.42 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Doyle K, et al. 2010. Post by OneWorld Health.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting