• Product NameAZ5104
• Brief DescriptionInhibitors
• Purification99.59%
• Biological ActivityAZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.
• Target NameEGFR inhibitor
• CAS No. 1421373-98-9
• Calculated MW 485.58
• Formulation C27H31N7O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=C(NC2=NC=CC(=N2)C2=CNC3=CC=CC=C23)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR (L858R); EGFR (L858R/T790M); EGFR (L861Q); EGFR (wildtype); HER2/ErbB2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 23 mg/mL warmed (47.36 mM); DMSO: 97 mg/mL (199.76 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Cross DA, et al. Y Discov. 2014, 4(9), 1046-1061.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting