• Product NamePerifosine (KRX-0401)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityPerifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.
• Target NameAkt inhibitor
• CAS No. 157716-52-4
• Calculated MW 461.66
• Formulation C25H52NO4P
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCCCCCCCCCCCCCCCCCOP(O)(=O)OC1CC[N+](C)(C)CC1
  Pathways:Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
  Receptor:Akt
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 15 mg/mL (32.49 mM); Water: 8 mg/mL (17.32 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Vyomesh Patel, et al. Y Res, 2002, 62(5), 1401-1409

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting