• Product NameCilengitide
• Brief DescriptionInhibitors
• Purification97.00%
• Biological ActivityCilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
• Target NameIntegrin inhibitor
• CAS No. 188968-51-6
• Calculated MW 588.66
• Formulation C27H40N8O7
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N
  Pathways:Cytoskeletal Signaling
  Receptor:αVβ3 integrin; αVβ5 integrin
  Boling pt:
  Melting pt:
  Solubility:Water: 8 mg/mL (13.59 mM); DMSO: 100 mg/mL (169.87 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Reardon DA, et al. Genes Y, 2011, 2(12):1159-1165.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting