• Product NameSemaxanib (SU5416)
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivitySemaxanib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR. Phase 3.
• Target NameVEGFR inhibitor
• CAS No. 194413-58-6
• Calculated MW 238.28
• Formulation C15H14N2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC(=C(N1)/C=C\2/C3=CC=CC=C3NC2=O)C
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:VEGFR2/Flk1
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL (8.39 mM); DMSO: 22 mg/mL (92.32 mM)
  Appearance:Orange Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Fong TA, et al. Y Res, 1999, 59(1), 99-106.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting