• Product NamePAC1
• Brief DescriptionInhibitors
• Purification98.64%
• Biological ActivityPAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3.
• Target NameCaspase activator
• CAS No. 315183-21-2
• Calculated MW 392.49
• Formulation C23H28N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C=CCC1=CC=C/C(=C/NNC(=O)CN2CCN(CC2)CC3=CC=CC=C3)/C1=O
  Pathways:Apoptosis; Proteases/Proteasome
  Receptor:Procaspase-3
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 16 mg/mL (40.76 mM); DMSO: 78 mg/mL (198.73 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Putt KS, et al. Nat Chem Biol, 2006, 2(10), 543-550.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting