• Product NameS3I-201;NSC 74859
• Brief DescriptionInhibitors
• Purification99.46%
• Biological ActivityS3I-201 shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM in cell-free assays, and low activity towards STAT1 and STAT5.
• Target NameSTAT inhibitor
• CAS No. 501919-59-1
• Calculated MW 365.36
• Formulation C16H15NO7S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC1=CC(O)=C(C=C1)C(O)=O
  Pathways:JAK/STAT signaling; Stem Cells
  Receptor:STAT3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 73 mg/mL (199.8 mM)
  Appearance:Khaki Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Siddiquee K, et al. Proc Natl Acad Sci U S A, 2007, 104(18), 7391-7396.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting