• Product NameAZD5438
• Brief DescriptionInhibitors
• Purification98.70%
• Biological ActivityAZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM in cell-free assays. It is less potent to CDK5/6 and also inhibits GSK3β. Phase 1.
• Target NameCDK inhibitor
• CAS No. 602306-29-6
• Calculated MW 371.46
• Formulation C18H21N5O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)N1C(C)=NC=C1C1=NC(NC2=CC=C(C=C2)S(C)(=O)=O)=NC=C1
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK1; CDK2; CDK9
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 74 mg/mL (199.21 mM); DMSO: 74 mg/mL (199.21 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Byth KF, et al. Mol Y Ther. 2009, 8(7), 1856-1866.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting