• Product NameBinimetinib (MEK162, ARRY-162, ARRY-438162)
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityBinimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Phase 3.
• Target NameMEK inhibitor
• CAS No. 606143-89-9
• Calculated MW 441.23
• Formulation C17H15BrF2N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1C=NC2=C1C=C(C(=O)NOCCO)C(NC1=C(F)C=C(Br)C=C1)=C2F
  Pathways:MAPK
  Receptor:MEK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 88 mg/mL (199.44 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. SS Bhagwat, et al. Annu Rep Med Chem, 2007, 42, 265C278.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting