• Product NameGalunisertib (LY2157299)
• Brief DescriptionInhibitors
• Purification99.85%
• Biological ActivityLY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM.
• Target NameTGF-beta/Smad inhibitor
• CAS No. 700874-72-2
• Calculated MW 369.42
• Formulation C22H19N5O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CC1=CC=CC(=N1)C1=NN2CCCC2=C1C1=C2C=C(C=CC2=NC=C1)C(N)=O
  Pathways:Stem Cells
  Receptor:TβRI
  Boling pt:
  Melting pt:
  Solubility:DMSO: 74 mg/mL (200.31 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Yingling JM, et al. Proc Am Assoc Y Res. 2006, 47, abstract 250.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting