• Product NamePlinabulin (NPI-2358)
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityPlinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.
• Target NameMicrotubule Associated inhibitor
• CAS No. 714272-27-2
• Calculated MW 336.39
• Formulation C19H20N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:CC(C)(C)C1=C(N=CN1)/C=C\2/C(=O)N/C(=C\C3=CC=CC=C3)/C(=O)N2
  Pathways:Cytoskeletal Signaling
  Receptor:Tubulin
  Boling pt:
  Melting pt:
  Solubility:DMSO: 54 mg/mL warmed (160.52 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Nicholson B, et al. AntiY Drugs, 2006, 17(1), 25-31.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting