• Product NameMocetinostat (MGCD0103)
• Brief DescriptionInhibitors
• Purification99.74%
• Biological ActivityMocetinostat (MGCD0103) is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2- to 10- fold selectivity against HDAC2, 3, and 11, and no activity to HDAC4, 5, 6, 7, and 8. Phase 2.
• Target NameHDAC inhibitor
• CAS No. 726169-73-9
• Calculated MW 396.44
• Formulation C23H20N6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:NC1=CC=CC=C1NC(=O)C1=CC=C(CNC2=NC=CC(=N2)C2=CN=CC=C2)C=C1
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair; NF-κb
  Receptor:HDAC1; HDAC11; HDAC2; HDAC3; HDAC4
  Boling pt:
  Melting pt:
  Solubility:DMSO: 13 mg/mL (32.79 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Fournel M, et al. Mol Y Ther. 2008, 7(4), 759-768.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting