• Product NameVX-702
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityVX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β. Phase 2.
• Target Namep38 MAPK inhibitor
• CAS No. 745833-23-2
• Calculated MW 404.3
• Formulation C19H12F4N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:NC(=O)N(C1=NC(=C(C=C1)C(N)=O)C1=C(F)C=C(F)C=C1)C1=C(F)C=CC=C1F
  Pathways:MAPK
  Receptor:p38α
  Boling pt:
  Melting pt:
  Solubility:DMSO: 81 mg/mL (200.34 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kuliopulos A, et al. Thromb Haemost, 2004, 92(6), 1387-1393.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting