• Product NameRoxadustat (FG-4592)
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityRoxadustat (FG-4592) is an HIF α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Phase 3.
• Target NameHIF inhibitor
• CAS No. 808118-40-3
• Calculated MW 352.34
• Formulation C19H16N2O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CC1=NC(C(=O)NCC(O)=O)=C(O)C2=C1C=C(OC1=CC=CC=C1)C=C2
  Pathways:Angiogenesis; Chromatin/Epigenetic
  Receptor:HIF-PH
  Boling pt:
  Melting pt:
  Solubility:DMSO: 70 mg/mL (198.67 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Seeley, TW, et al. U.S. Pat. Appl. Publ. 2007, US 20070292433 A1 20071220.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting