• Product NameAmuvatinib(MP470)
• Brief DescriptionInhibitors
• Purification98.48%
• Biological ActivityAmuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Phase 2.
• Target Namec-Kit inhibitor; FLT inhibitor; PDGFR inhibitor
• CAS No. 850879-09-3
• Calculated MW 447.51
• Formulation C23H21N5O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:S=C(NCC1=CC2=C(OCO2)C=C1)N1CCN(CC1)C1=NC=NC2=C1OC1=CC=CC=C21
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:c-Kit (D816H); FLT3 (D835Y); PDGFRα (V561D)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 32 mg/mL (71.5 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Mahadevan D, et al. Oncogene, 2007, 26(27), 3909-3919.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting