• Product NameMK-8776 (SCH 900776)
• Brief DescriptionInhibitors
• Purification96.69%
• Biological ActivityMK-8776 (SCH 900776) is a selective Chk1 inhibitor with IC50 of 3 nM in a cell-free assay. It shows 500-fold selectivity against Chk2. Phase 2.
• Target NameCDK inhibitor; Chk inhibitor
• CAS No. 891494-63-6
• Calculated MW 376.25
• Formulation C15H18BrN7
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1C=C(C=N1)C2=C3N=C(C(=C(N3N=C2)N)Br)[C@@H]4CCCNC4
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK2; Chk1; Chk2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 3 mg/mL (7.97 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Guzi TJ, et al. Mol Y Ther, 2011, 10(4), 591-602.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting