• Product NameARRY380
• Brief DescriptionInhibitors
• Purification99.09%
• Biological ActivityARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR.
• Target NameEGFR inhibitor; HER inhibitor
• CAS No. 937265-83-3
• Calculated MW 569.63
• Formulation C29H27N7O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C(OC2=CC3=NC=NN3C=C2)C=CC(NC2=NC=NC3=C2C=C(C=C3)C2=CC=C(CNCCS(C)(=O)=O)O2)=C1
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR; HER2; p95-HER2
  Boling pt:
  Melting pt:
  Solubility:DMSO: > 10mM
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Madala SK, et al. Am J Respir Cell Mol Biol. 2012 Mar;46(3):380-8.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting