• Product NamePimozide
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityPimozide is a diphenylbutylpiperidine derivative and a dopamine antagonist with antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the central nervous system (CNS), thereby decreasing dopamine neurotransmission and reducing the occurrence of motor and vocal tics and delusions of parasitosis. In addition, this agent antagonizes alpha-adrenergic and 5-HT2 receptors.
• Target NameDopamine Receptor antagonist; Potassium Channel inhibitor
• CAS No. 2062-78-4
• Calculated MW 461.55
• Formulation C28H29F2N3O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:FC1=CC=C(C=C1)C(CCCN1CCC(CC1)N1C(=O)NC2=CC=CC=C12)C1=CC=C(F)C=C1
  Pathways:GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
  Receptor:D2; Potassium Channel
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Silva MR, et al. Pharmacol Toxicol. 2003 Jul;93(1):42-7.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting