• Product NameMacitentan
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityMacitentan is an orally active, non-peptide, dual ETA/ETB (endothelin) receptor antagonist with IC50 of 0.5 nM/391 nM.
• Target NameEndothelin Receptor antagonist
• CAS No. 441798-33-0
• Calculated MW 588.27
• Formulation C19H20Br2N6O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:CCCNS(O)(O)NC1=C(C(OCCOC2=NC=C(Br)C=N2)=NC=N1)C1=CC=C(Br)C=C1
  Pathways:GPCR/G Protein
  Receptor:ET-A; ET-B
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL (169.98 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Iglarz M, et al. J Pharmacol Exp Ther, 2008, 327(3), 736-745.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting