• Product NameEltrombopag
• Brief DescriptionInhibitors
• Purification99.82%
• Biological ActivityEltrombopag is an orally active thrombopoietin receptor agonist with megakaryopoiesis stimulating activity. Eltrombopag binds to and stimulates the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of megakaryocytes, thereby increasing the production of blood platelets.
• Target NameThrombin agonist
• CAS No. 496775-61-2
• Calculated MW 442.47
• Formulation C25H22N4O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N/N=C/3\C=CC=C(C3=O)C4=CC(=CC=C4)C(=O)O)C
  Pathways:Others
  Receptor:Thrombopoietin receptor
  Boling pt:
  Melting pt:
  Solubility:DMSO: 26 mg/mL warmed (58.76 mM)
  Appearance:Red Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kuter DJ. Annu Rev Med. 2009;60:193-206.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting