• Product NameBrivanib Alaninate (BMS-582664)
• Brief DescriptionInhibitors
• Purification99.66%
• Biological ActivityBrivanib alaninate (BMS-582664) is the prodrug of BMS-540215, an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM.
• Target NameFGFR inhibitor; VEGFR inhibitor
• CAS No. 649735-63-7
• Calculated MW 441.46
• Formulation C22H24FN5O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OC[C@@H](C)OC(=O)[C@H](C)N)C
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:FGFR1; Flk1; VEGFR1; VEGFR2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 88 mg/mL (199.33 mM); DMSO: 88 mg/mL (199.33 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bhide RS, et al. J Med Chem, 2006, 49(7), 2143-2146.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting