• Product NameApatinib
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityApatinib is an orally bioavailable, selective VEGFR2 inhibitor with IC50 of 1 nM.
• Target Namec-Kit inhibitor; c-RET inhibitor; Src inhibitor; VEGFR inhibitor
• CAS No. 811803-05-1
• Calculated MW 397.48
• Formulation C24H23N5O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CS(O)(=O)=O.O=C(NC1=CC=C(C=C1)C1(CCCC1)C#N)C1=C(NCC2=CC=NC=C2)N=CC=C1
  Pathways:Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
  Receptor:c-Kit; RET; c-Src; VEGFR2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 22 mg/mL (44.57 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tian S, et al. Y Sci, 2011, 102(7), 1374-1380.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting