• Product NameCilastatin
• Brief DescriptionInhibitors
• Purification99.71%
• Biological ActivityA renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
• Target NameProteasome inhibitor
• CAS No. 82009-34-5
• Calculated MW 358.45
• Formulation C16H26N2O5S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CC1(C[C@H]1C(=O)N/C(=C\CCCCSC[C@H](C(=O)O)N)/C(=O)O)C
  Pathways:Proteases/Proteasome; Ubiquitination
  Receptor:Dipeptidase 1
  Boling pt:
  Melting pt:156-158C
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Farrell CA, et al. Arch Biochem Biophys. 1987 Jul;256(1):253-9.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting