• Product NameCabozantinib (XL184, BMS-907351)
• Brief DescriptionInhibitors
• Purification99.71%
• Biological ActivityCabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively.
• Target Namec-Kit inhibitor; c-Met/HGFR inhibitor; TAM Receptor inhibitor; VEGFR inhibitor
• CAS No. 849217-68-1
• Calculated MW 501.5
• Formulation C28H24FN3O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC2=NC=CC(OC3=CC=C(C=C3)N(C(=O)C3(CC3)C(N)=O)C3=CC=C(F)C=C3)=C2C=C1OC
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:Kit; c-Met; AXL; VEGFR2/KDR; VEGFR3/FLT4
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL (199.39 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. You WK, et al. Y Res, 2011, 71(14), 4758-4768.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting