• Product NameIvacaftor (VX-770)
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityIvacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM in fisher rat thyroid cells, respectively.
• Target NameCFTR potentiator
• CAS No. 873054-44-5
• Calculated MW 392.49
• Formulation C24H28N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)(C)C1=CC(=C(O)C=C1NC(=O)C1=CNC2=CC=CC=C2C1=O)C(C)(C)C
  Pathways:Membrane transporter/Ion channel
  Receptor:F508del-CFTR; G551D-CFTR
  Boling pt:
  Melting pt:
  Solubility:DMSO: 78 mg/mL (198.73 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Van Goor F, et al. Proc Natl Acad Sci U S A, 2009, 106(44), 18825-18830.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting