• Product NameVismodegib (GDC-0449)
• Brief DescriptionInhibitors
• Purification98.84%
• Biological ActivityVismodegib(GDC-0449) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM; also inhibits P-gp with IC50 of 3.0 μM.
• Target NameHedgehog/Smoothened antagonist
• CAS No. 879085-55-9
• Calculated MW 421.3
• Formulation C19H14Cl2N2O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CS(=O)(=O)C1=CC(Cl)=C(C=C1)C(=O)NC1=CC(=C(Cl)C=C1)C1=CC=CC=N1
  Pathways:GPCR/G Protein; Stem Cells
  Receptor:Hedgehog
  Boling pt:
  Melting pt:
  Solubility:DMSO: 84 mg/mL (199.38 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tian F, et al. AntiY Res. 2012, 32(1), 89-94.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting