• Product NameVeliparib (ABT-888)
• Brief DescriptionInhibitors
• Purification98.92%
• Biological ActivityVeliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.
• Target NamePARP inhibitor
• CAS No. 912444-00-9
• Calculated MW 244.29
• Formulation C13H16N4O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@@]1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair
  Receptor:PARP1; PARP2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 17 mg/mL (69.58 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Albert JM, et al, Clin Y Res, 2007, 13(10), 3033-3042.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting