• Product NameAG-490 (Tyrphostin B42)
• Brief DescriptionInhibitors
• Purification98.60%
• Biological ActivityAG-490 (Tyrphostin AG 490) is an inhibitor of EGFR with IC50 of 0.1 μM, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.
• Target NameEGFR inhibitor; JAK inhibitor
• CAS No. 133550-30-8
• Calculated MW 294.3
• Formulation C17H14N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
  Pathways:Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Tyrosine Kinase/Adaptors; Stem Cells
  Receptor:EGFR; HER2/ErbB2; JAK2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 6 mg/mL (20.38 mM); DMSO: 59 mg/mL (200.47 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Samanta AK, et al. Y Res, 2006, 66(13), 6468-6472.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting