• Product NameCC-292 (AVL-292)
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityCC-292 (AVL-292) is a covalent, orally active, and highly selective BTK inhibitor with IC50 of <0.5 nM, displaying at least 1400-fold selectivity over the other kinases assayed. Phase 1.
• Target NameBTK inhibitor; Src inhibitor
• CAS No. 1202757-89-8
• Calculated MW 423.44
• Formulation C22H22FN5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COCCOC1=CC=C(NC2=NC=C(F)C(NC3=CC(NC(=O)C=C)=CC=C3)=N2)C=C1
  Pathways:Angiogenesis
  Receptor:BRK; BTK; c-Src; Lyn; Yes
  Boling pt:
  Melting pt:
  Solubility:DMSO: 85 mg/mL (200.73 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Evans E, et al. ASH Annual Meeting, 2011 San Diego, CA.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting