• Product NameR788 (Fostamatinib) Disodium
• Brief DescriptionInhibitors
• Purification97.53%
• Biological ActivityR788 (Fostamatinib) disodium, a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.
• Target NameSyk inhibitor
• CAS No. 1025687-58-4
• Calculated MW 624.42
• Formulation C23H24FN6O9P2Na
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:[Na+].[Na+].COC1=CC(NC2=NC=C(F)C(NC3=NC4=C(OC(C)(C)C(=O)N4COP([O-])([O-])=O)C=C3)=N2)=CC(OC)=C1OC
  Pathways:Angiogenesis
  Receptor:Syk
  Boling pt:
  Melting pt:
  Solubility:DMSO: 0.4 mg/mL (0.64 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Braselmann S, et al. J Pharmacol Exp Ther, 2006, 319(3), 998-1008.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting