• Product NameMasitinib (AB1010)
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityMasitinib is a novel inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms. Phase 3.
• Target NameBcr-Abl inhibitor; c-Fms inhibitor; c-Kit inhibitor; Hck inhibitor; PDGFR inhibitor; Src inhibitor
• CAS No. 790299-79-5
• Calculated MW 498.64
• Formulation C28H30N6OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1CCN(CC2=CC=C(C=C2)C(=O)NC2=CC(NC3=NC(=CS3)C3=CN=CC=C3)=C(C)C=C2)CC1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling
  Receptor:Abl1; c-Fms; Kit; Hck; PDGFRα; PDGFRβ; Lyn B; Src
  Boling pt:
  Melting pt:90-95C
  Solubility:Ethanol: 4 mg/mL (8.02 mM); DMSO: 100 mg/mL (200.54 mM)
  Appearance:Faint Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Dubreuil P, et al. PLoS One, 2009, 4(9), e7258.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting