• Product NameBMS 599626
• Brief DescriptionInhibitors
• Purification98.79%
• Biological ActivityAC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1.
• Target NameHER inhibitor; MEK inhibitor; Src inhibitor
• CAS No. 714971-09-2
• Calculated MW 530.55
• Formulation C27H27FN8O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C2C(=NC=NN2C=C1NC(=O)OC[C@@H]3COCCN3)NC4=CC5=C(C=C4)N(N=C5)CC6=CC(=CC=C6)F
  Pathways:Angiogenesis; MAPK; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:HER1; HER2; HER4; MEK; Lck
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 20 mg/mL (35.27 mM); DMSO: 113 mg/mL (199.29 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wong TW, et al. Clin Y Res, 2006, 12(20 Pt 1), 6186-6193.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting