• Product NameCCT137690
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityCCT137690 is a highly selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 15 nM, 25 nM and 19 nM. It has little effect on hERG ion-channel.
• Target NameAurora Kinase inhibitor
• CAS No. 1095382-05-0
• Calculated MW 551.48
• Formulation C26H31BrN8O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1CCN(CC1)C1=CC=C(C=C1)C1=NC2=NC=C(Br)C(N3CCN(CC4=NOC(C)=C4)CC3)=C2N1
  Pathways:Cell Cycle/Checkpoint; Chromatin/Epigenetic
  Receptor:Aurora A; Aurora B; Aurora C
  Boling pt:
  Melting pt:
  Solubility:DMSO: 4 mg/mL (7.25 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bavetsias V, et al. J Med Chem, 2010, 53(14), 5213-5228.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting